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| Nomenclature |
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Symbol:
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Tg(tetO-SNCA*A53T)33Vle
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Name:
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transgene insertion 33, Virginia M-Y Lee
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MGI ID: |
MGI:5289968 |
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Synonyms: |
tetP-A53Talpha-syn |
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Transgene:
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Tg(tetO-SNCA*A53T)33Vle
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x C3H)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene consists of the human alpha-synuclein cDNA encoding a mutated protein with an Ala53Thr mutation under the control of the tetracycline responsive promoter. The mutant alpha-synuclein is expressed only in the presence of the tetracycline transactivator (tTA), expressed from a second transgene; administration of doxycycline inhibits tTA binding to tetO, thus suppressing alpha-synuclein expression. (J:156801)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:156801
Lim Y et al.,
"Forebrain overexpression of alpha-synuclein leads to early postnatal hippocampal neuron loss and synaptic disruption."
Exp Neurol 2010 Jan;221(1):86-97
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All: |
2 reference(s)
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Analysis Tools
