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| Nomenclature |
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Symbol:
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Spink5Tn(Pgk2-sb10,sb-Tyr)1498Ove
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Name:
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serine peptidase inhibitor, Kazal type 5;
transposon insertion 1498, Paul A Overbeek
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MGI ID: |
MGI:5286986 |
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Synonyms: |
OVE1498 |
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Gene:
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Spink5
Location:
Chr18:43963235-44022501 bp, + strand
Genetic Position: Chr18,
23.74 cM
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Mutation
origin |
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Mutation
description |
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Allele
Type: | |
Transposon induced |
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Mutations: | |
Insertion, Intergenic deletion |
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Mutation details: A transposon transgene containing mouse Pgk2 driving expression of sleeping beauty 10 (SB10) and a mouse tyrosinase minigene driven by a Tyr enhancer flanked by Sleeping Beauty inverted repeats (termed
pT-Tybs-3'E) were co-injected with a Pgk2 driven SB10. In line 1498, transposon and transposase co-integration results in a 66.8 kb deletion containing the coding exons of the targeted gene and none of the coding regions of the genes flanking the integration site. RT-PCR confirmed the absence of transcript expression at P0 skin cDNA. (J:93050)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:93050
Yang T et al.,
"Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice."
Genes Dev 2004 Oct 1;18(19):2354-8
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All: |
1 reference(s)
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Analysis Tools
