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| Nomenclature |
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Symbol:
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Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy
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Name:
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gene trap ROSA 26, Philippe Soriano;
targeted mutation 1.1, Andras Nagy
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MGI ID: |
MGI:5286599 |
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Synonyms: |
ROSA26rtTA |
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Gene:
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Gt(ROSA)26Sor
Location:
Chr6:113067428-113077333 bp, - strand
Genetic Position: Chr6,
52.73 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:174960
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: A targeting vector containing a floxed Pgk-neo-pA cassette and a rtTA-IRES-EGFP-pA cassette was inserted into intron 1 of the locus. Cre-mediated recombination removed the floxed neo cassette allowing the ROSA26 promoter to drive expression of rtTA and EGFP. Presence of doxycycline results in the formation of an active transcriptional activator and the activation of the responder transgene. (J:174960)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:174960
Le TT et al.,
"Temporal requirement for high SMN expression in SMA mice."
Hum Mol Genet 2011 Sep 15;20(18):3578-91
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All: |
1 reference(s)
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Analysis Tools
