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| Nomenclature |
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Symbol:
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Tg(Prnp-HTT*82Q,KRT14-EGFP)C63Dbo
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Name:
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transgene insertion C63, David R Borchelt
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MGI ID: |
MGI:5286114 |
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Synonyms: |
N586-82Q-C63 |
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Transgene:
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Tg(Prnp-HTT*82Q,KRT14-EGFP)C63Dbo
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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Not Specified
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Transgene
description |
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Transgene
Type: | |
Transgenic (Reporter) |
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Mutation: | |
Insertion |
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Mutation details: The mouse promoter drives brain-specific expression of the human cDNA encoding the first 586 N-terminal amino acids (N586) and an expansion of the glutamine tract to 82 (82Q). The transgene was co-integrated with a transgene in which the human promoter drives skin-specific expression fo EGFP. Lines C62 and C63 were generated with the later expressing at higher levels than the former. (J:173756)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:173756
Tebbenkamp AT et al.,
"Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative."
Hum Mol Genet 2011 Jul 15;20(14):2770-82
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All: |
1 reference(s)
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Analysis Tools
