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| Nomenclature |
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Symbol:
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Nrg1m1Yzcm
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Name:
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neuregulin 1;
mutation 1, Yangzhou University Comparative Medicine Center
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MGI ID: |
MGI:5285952 |
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Synonyms: |
Nrg1Dp1 |
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Gene:
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Nrg1
Location:
Chr8:31818028-31918203 bp, - strand
Genetic Position: Chr8,
18.75 cM
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Dilated pupils in Nrg1m1Yzcm/Nrg1+ and Nrg1m1Yzcm/Nrg1m1Yzcm mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Strain of Origin:
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C57BL/6J
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Mutation
description |
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Allele
Type: | |
Chemically induced (ENU) |
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Mutation: | |
Single point mutation |
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Mutation details: ENU mutagenesis induced a G to A transition in the 5' splice donor site downstream of exon 59. RT-PCR confirmed the expression of multiple transcripts of different lengths. (J:175524)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Nrg1 Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:175524
Chen B et al.,
"An ENU-Induced Mutation of Nrg1 Causes Dilated Pupils and a Reduction in Muscarinic Receptors in the Sphincter Pupillae"
PLoS ONE 2011;6(9):e25176
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All: |
1 reference(s)
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Analysis Tools
