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| Nomenclature |
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Symbol:
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Lgr5tm2.1Cle
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Name:
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leucine rich repeat containing G protein coupled receptor 5;
targeted mutation 2.1, Hans Clevers
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MGI ID: |
MGI:5285688 |
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Synonyms: |
Lgr5fl |
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Gene:
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Lgr5
Location:
Chr10:115450311-115587780 bp, - strand
Genetic Position: Chr10,
63.51 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:174842
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP site was inserted upstream of exon 16. A floxed neo cassette was inserted downstream of exon 16. Cre-mediated recombination removed the neo cassette and left exon 16 floxed. (J:174842)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Lgr5 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:174842
de Lau W et al.,
"Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling."
Nature 2011 Aug 18;476(7360):293-7
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All: |
1 reference(s)
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Analysis Tools
