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| Nomenclature |
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Symbol:
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Tg(Thy1-HSPB1*P182L)#Lvdb
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Name:
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transgene insertion, Ludo Van Den Bosch
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MGI ID: |
MGI:5285201 |
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Synonyms: |
HSPB1P182L, S135F |
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Transgene:
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Tg(Thy1-HSPB1*P182L)#Lvdb
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene construct contains the human HSPB2 cDNA harboring the P182L mutation coupled to an N-terminal hemagglutinin (HA) tag driven by the murine Thy1.2 expression cassette. The transgene is expressed in the gray matter and in extended processes in the white matter. A # is used to indicate that a line number was not provided in the original publication. (J:174508)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:174508
d'Ydewalle C et al.,
"HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease."
Nat Med 2011;17(8):968-74
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All: |
1 reference(s)
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Analysis Tools
