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| Nomenclature |
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Symbol:
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Trpm2tm1.1Alp
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Name:
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transient receptor potential cation channel, subfamily M, member 2;
targeted mutation 1.1, Anne-Laure Perraud
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MGI ID: |
MGI:5284866 |
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Synonyms: |
TRPM2delta19/20 |
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Gene:
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Trpm2
Location:
Chr10:77907722-77970563 bp, - strand
Genetic Position: Chr10,
39.72 cM
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Trpm2tm1.1Alp/Trpm2tm1.1Alp and Ifngr1tm1Agt/Ifngr1tm1Agt mice exhibit increased susceptibility to bacterial infection
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:174397
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (other) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 19 and 20 were floxed by inserting a floxed neo cassette into intron 18 and an additional loxP site in intron 20. Cre-mediated recombination removed exons 19 and 20 and the neo cassette. The absence of transcripts containing exon 20 was confirmed by RT-PCR on brain extracts. (J:174397)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Trpm2 Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:174397
Knowles H et al.,
"Transient Receptor Potential Melastatin 2 (TRPM2) ion channel is required for innate immunity against Listeria monocytogenes."
Proc Natl Acad Sci U S A 2011 Jul 12;108(28):11578-83
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All: |
2 reference(s)
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Analysis Tools
