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| Nomenclature |
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Symbol:
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Fostm3.1Wag
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Name:
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FBJ osteosarcoma oncogene;
targeted mutation 3.1, Erwin F Wagner
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MGI ID: |
MGI:5142238 |
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Synonyms: |
Fos362A |
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Gene:
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Fos
Location:
Chr12:85473890-85477273 bp, + strand
Genetic Position: Chr12,
39.7 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:175064
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Parent Cell Line:
| HM-1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd-Hprtb-m3
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Nucleotide substitutions |
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Mutation details: Exon 4 was replaced with a modified exon in which nucleotide substitutions result in the amino acid substitution of alanine for serine at position 362 (S362A). Flp-mediated recombination removed the floxed neo cassette inserted downstream of the endogenous polyadenylation sequence and left an EGFP gene with a 5' loxP site intact. (J:175064)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Fos Mutation:
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15 strains or lines available |
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| References |
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Original: |
J:175064
Bakiri L et al.,
"Functions of Fos phosphorylation in bone homeostasis, cytokine response and tumourigenesis."
Oncogene 2011 Mar 31;30(13):1506-17
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All: |
1 reference(s)
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Analysis Tools
