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| Nomenclature |
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Symbol:
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Tg(Pcp2-TBP*)69Hmhl
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Name:
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transgene insertion 69, Hsiu M Hsieh-Li
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MGI ID: |
MGI:5142235 |
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Synonyms: |
hTBP-109Q, L7-hTBP |
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Transgene:
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Tg(Pcp2-TBP*)69Hmhl
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene consists of the full-length human TATA box binding protein, TBP, with the 36 CAA/CAG repeat region expanded to 109 repeats under the control of the mouse Pcp2 promoter. A copy number of 10-20 is seen for line 69. Expression of the transgene occurs mainly in the cerebellum and brainstem, and at lower levels in cortex and hippocampus. (J:174239)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Notes |
Four lines were made in J:174239, lines 20, 54, 69, and 71.
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| References |
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Original: |
J:174239
Chang YC et al.,
"Neuroprotective effects of granulocyte-colony stimulating factor in a novel transgenic mouse model of SCA17."
J Neurochem 2011 Jul;118(2):288-303
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All: |
1 reference(s)
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Analysis Tools
