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| Nomenclature |
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Symbol:
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Unc93b1tm1.1Kmiy
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Name:
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unc-93 homolog B1 (C. elegans);
targeted mutation 1.1, Kensuke Miyake
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MGI ID: |
MGI:5140947 |
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Synonyms: |
Unc93b1D34A |
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Gene:
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Unc93b1
Location:
Chr19:3935186-3949340 bp, + strand
Genetic Position: Chr19,
3.65 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:174308
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Single point mutation |
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Mutation details: Exon 2 was replaced with one in which an A to C mutation results in the amino acid substitution of alanine for aspartic acid at position 34 (D34A). A floxed neo cassette inserted downstream of exon 3 was removed by cre-mediated recombination. (J:174308)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
ES cell line EB3, derived from E14TG2a, carries one allele of Pou5f1 that has been inactivated by targeted integration of E14TG2a ES cells with an IRESBSDpA selection cassette. J:174308 does not mention whether the null allele of Pou5f1 is also present in the line of mice created.
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| References |
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Original: |
J:174308
Fukui R et al.,
"Unc93B1 Restricts Systemic Lethal Inflammation by Orchestrating Toll-like Receptor 7 and 9 Trafficking."
Immunity 2011 Jul 22;35(1):69-81
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All: |
1 reference(s)
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Analysis Tools
