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| Nomenclature |
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Symbol:
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Shank3tm1.1Pfw
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Name:
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SH3/ankyrin domain gene 3;
targeted mutation 1.1, Paul Worley
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MGI ID: |
MGI:5085999 |
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Synonyms: |
Shank3(deltaC), Shank3tm1.1Bxia |
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Gene:
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Shank3
Location:
Chr15:89499623-89560261 bp, + strand
Genetic Position: Chr15,
44.96 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:173397
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (other) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A loxP site was inserted upstream of exon 21. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 21. Cre-mediated recombination removed exon 21 and the neo cassette. (J:173397)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:173397
Bangash MA et al.,
"Enhanced Polyubiquitination of Shank3 and NMDA Receptor in a Mouse Model of Autism."
Cell 2011 May 27;145(5):758-72
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All: |
1 reference(s)
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Analysis Tools
