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| Nomenclature |
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Symbol:
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Ccm2tm2.1Sbn
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Name:
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cerebral cavernous malformation 2;
targeted mutation 2.1, Ulrich Siebenlist
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MGI ID: |
MGI:5085315 |
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Synonyms: |
Ccm2flox |
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Gene:
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Ccm2
Location:
Chr11:6546887-6596744 bp, + strand
Genetic Position: Chr11,
4.45 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:174085
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP site was inserted upstream of exon 3 and an FRT flanked neo cassette and second loxP site were inserted downstream of exon 4 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:174085)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ccm2 Mutation:
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31 strains or lines available |
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| References |
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Original: |
J:174085
Cunningham K et al.,
"Conditional deletion of Ccm2 causes hemorrhage in the adult brain: a mouse model of human cerebral cavernous malformations."
Hum Mol Genet 2011 Aug 15;20(16):3198-206
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All: |
1 reference(s)
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Analysis Tools
