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| Nomenclature |
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Symbol:
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Tg(JPH3-GFP,-JPH3*)GXwy
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Name:
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transgene insertion G, X William Yang
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MGI ID: |
MGI:5052365 |
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Synonyms: |
BAC-HDL2-STOP |
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Transgene:
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Tg(JPH3-GFP,-JPH3*)GXwy
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The human BAC (RP11-33A21) was modified to include a transcriptional stop sequence (GFP followed by a floxed pgk-neo cassette and a polyA signal) before exon 1 and an expanded CTG/CAG track of 120 repeats in exon 2A of JPH3. RT-PCR confirmed that expression of the sense strand CUG repeat is silenced but expression of the antisense CAG repeat is retained. (J:174267)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:174267
Wilburn B et al.,
"An antisense CAG repeat transcript at JPH3 locus mediates expanded polyglutamine protein toxicity in Huntington's disease-like 2 mice."
Neuron 2011 May 12;70(3):427-40
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All: |
1 reference(s)
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Analysis Tools
