|
|
| Nomenclature |
|
Symbol:
|
Tg(Mapt-MAPT*)#Hanr
|
|
Name:
|
transgene insertion, Hanna Rosenmann
|
|
MGI ID: |
MGI:5052111 |
|
Synonyms: |
DM-htau |
|
Transgene:
|
Tg(Mapt-MAPT*)#Hanr
Location:
unknown
|
|
Transgene
origin |
|
Strain of Origin:
|
C57BL/6 x BALB/c
|
|
Transgene
description |
|
Transgene
Type: | |
Transgenic (random, expressed) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: A fragment of the rat Mapt promoter drives expression of a human MAPT cDNA coding for the short four repeat isoform, containing 2 pathogenic mutations, K257T and P301S. Expression of the mutant MAPT protein is about 5-10% that of the endogenous protein. (J:137947)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
|
Notes |
Phenotypic Similarity to Human Syndrome: tauopathy (J:137947)
|
| References |
|
Original: |
J:137947
Rosenmann H et al.,
"A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics."
Exp Neurol 2008 Jul;212(1):71-84
|
|
All: |
1 reference(s)
|
|
Analysis Tools
