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| Nomenclature |
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Symbol:
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Mcoln1tm1Asoy
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Name:
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mucolipin 1;
targeted mutation 1, Abigail Soyombo-Shoola
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MGI ID: |
MGI:5050099 |
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Synonyms: |
Trpml1- |
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Gene:
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Mcoln1
Location:
Chr8:3500457-3515232 bp, + strand
Genetic Position: Chr8,
1.92 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:173516
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
| |
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Mutation details: A tetracycline responsive transcriptional activator was place downstream of the promoter followed by a neomycin selection cassette. This insertion replaced exons 1 and 2 and part of exon 3. Northern blot analysis of brain RNA confirmed the absence of mRNA. (J:173516)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:173516
Chandra M et al.,
"A role for the Ca2+ channel TRPML1 in gastric acid secretion, based on analysis of knockout mice."
Gastroenterology 2011 Mar;140(3):857-67
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All: |
1 reference(s)
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Analysis Tools
