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| Nomenclature |
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Symbol:
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Pinx1tm1.1Kplu
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Name:
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PIN2/TERF1 interacting, telomerase inhibitor 1;
targeted mutation 1.1, Kun Ping Lu
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MGI ID: |
MGI:5013947 |
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Gene:
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Pinx1
Location:
Chr14:63860312-63919859 bp, + strand
Genetic Position: Chr14,
33.34 cM, cytoband C3
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Varied histopathology of Pinx1tm1.1Kplu/Pinx1+ tumors
Show the 12 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:171997
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Parent Cell Line:
| AB2.1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A loxP site was inserted upstream of exon 1. A floxed neo cassette was inserted downstream of exon 1. Cre-mediated recombination removed exon 1 and the neo cassette. The absence of transcript expression was confirmed by RT-PCR on E9.5 embryo extracts. (J:171997)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pinx1 Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:171997
Zhou XZ et al.,
"The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice."
J Clin Invest 2011 Apr 1;121(4):1266-82
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All: |
1 reference(s)
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Analysis Tools
