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| Nomenclature |
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Symbol:
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Tg(PDGFB-UCHL1*I93M)HWada
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Name:
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transgene insertion H, Keiji Wada
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MGI ID: |
MGI:5008738 |
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Synonyms: |
H-hI93M, hUCHL1I93M |
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Transgene:
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Tg(PDGFB-UCHL1*I93M)HWada
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6J
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The human PDGFB promoter drives expression of a human UCHL1 cDNA with an isoleucine to methionine mutation at amino acid 93(I93M). Two lines were generated. Line L had lower levels of transgene expression compared to line H. Expression of the transgene is detected in the many brain regions including the substantia nigra, subthalamic nuclei, striatum, hippocampus CA3 and cerebellum. (J:128045)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:128045
Setsuie R et al.,
"Dopaminergic neuronal loss in transgenic mice expressing the Parkinson's disease-associated UCH-L1 I93M mutant."
Neurochem Int 2007 Jan;50(1):119-29
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All: |
2 reference(s)
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Analysis Tools
