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| Nomenclature |
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Symbol:
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Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl
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Name:
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gene trap ROSA 26, Philippe Soriano;
targeted mutation 1, Merck Research Laboratory
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MGI ID: |
MGI:5007772 |
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Synonyms: |
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1,CAG-tetR)Mrl, Rosa26PDK1-RNAi |
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Gene:
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Gt(ROSA)26Sor
Location:
Chr6:113067428-113077333 bp, - strand
Genetic Position: Chr6,
52.73 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:170965
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: A construct containing a short hairpin RNA targeting Pdpk1 driven by the H1/tetO operator fusion promoter and a floxed CAG promoter driving expression of the tetR regulatory cassette was inserted into the locus. (J:170965)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gt(ROSA)26Sor Mutation:
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196 strains or lines available |
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| References |
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Original: |
J:170965
Ellwood-Yen K et al.,
"PDK1 Attenuation Fails to Prevent Tumor Formation in PTEN-Deficient Transgenic Mouse Models."
Cancer Res 2011 Apr 15;71(8):3052-65
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All: |
1 reference(s)
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Analysis Tools
