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| Nomenclature |
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Symbol:
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Tg(Myh6-Tpm1*E180G)57Dfw
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Name:
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transgene insertion 57, David F Wieczorek
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MGI ID: |
MGI:5007645 |
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Synonyms: |
FHC alpha-TM 180, Tm-E180G |
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Transgene:
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Tg(Myh6-Tpm1*E180G)57Dfw
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene consists of the murine alpha-myosin heavy chain cardiac-specific promoter ligated to the 5' end of the mouse alpha-tropomyosin with a single point mutation (GAG to GGG) corresponding to a glycine substitution for a glutamic acid at codon 180. This region interacts with troponin T. Quantification of the transgene demonstrates that copy number in line 57 is 22 copies. (J:127507, J:172340)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Notes |
Four lines, 33, 52, 57, and 58 were made (J:172340).
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| References |
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Original: |
J:127507
Prabhakar R et al.,
"A familial hypertrophic cardiomyopathy alpha-tropomyosin mutation causes severe cardiac hypertrophy and death in mice."
J Mol Cell Cardiol 2001 Oct;33(10):1815-28
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All: |
6 reference(s)
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Analysis Tools
