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| Nomenclature |
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Symbol:
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Tg(Hmgcr-PSEN1*M146L)#Lpr
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Name:
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transgene insertion, Laurent Pradier
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MGI ID: |
MGI:5003458 |
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Synonyms: |
HMG-PS1M146L |
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Transgene:
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Tg(Hmgcr-PSEN1*M146L)#Lpr
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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CBA x C57BL/6
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The murine Hmgcr promoter drives expression a human PSEN1 cDNA, which includes the intron between exons 4 and 5 and carries a methionine to leucine substitution at amino acid 146 (M146L). (J:86694)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:86694
Blanchard V et al.,
"Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice."
Exp Neurol 2003 Nov;184(1):247-63
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All: |
8 reference(s)
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Analysis Tools
