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| Nomenclature |
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Symbol:
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Tg(Prnp-TARDBP)3cPtrc
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Name:
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transgene insertion 3c, Leonard Petrucelli
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MGI ID: |
MGI:5002476 |
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Synonyms: |
TDP-43PrP, Tg(Prnp-TARDBP)3cLtrc |
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Transgene:
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Tg(Prnp-TARDBP)3cPtrc
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The TDP-43PrP transgene was designed with the human TAR DNA binding protein (TARDBP or TDP-43) gene driven by a mouse prion protein (Prnp) promoter. Line 3c was generated. (J:163231)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:163231
Xu YF et al.,
"Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice."
J Neurosci 2010 Aug 11;30(32):10851-9
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All: |
1 reference(s)
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Analysis Tools
