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| Nomenclature |
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Symbol:
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Tg(tetO-TARDBP)12Vle
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Name:
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transgene insertion 12, Virginia M Y Lee
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MGI ID: |
MGI:5000260 |
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Synonyms: |
hTDP-43-WT12 |
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Transgene:
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Tg(tetO-TARDBP)12Vle
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6J x C3H/HeJ)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The tetracycline responsive promoter drives inducible expression of the wild-type human cDNA. Four lines were generated (4, 5, 8, and 12). (J:170756)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:170756
Igaz LM et al.,
"Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice."
J Clin Invest 2011 Feb 1;121(2):726-38
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All: |
1 reference(s)
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Analysis Tools
