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| Nomenclature |
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Symbol:
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Guca1atm1.1Hunt
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Name:
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guanylate cyclase activator 1a (retina);
targeted mutation 1.1, David M Hunt
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MGI ID: |
MGI:4999776 |
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Synonyms: |
Guca1aCOD3 |
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Gene:
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Guca1a
Location:
Chr17:47394560-47400584 bp, - strand
Genetic Position: Chr17,
23.07 cM, cytoband D
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:171667
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129/Sv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: Exon 4 was replaced with a floxed neo cassette and a modified exon 4, which contained an A to G transition that results in the amino acid substitution of glycine for glutamic acid at position 155 (E155G). Cre-mediated recombination removed the neo cassette. (J:171667)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Guca1a Mutation:
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0 strains or lines available |
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| References |
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Original: |
J:171667
Buch PK et al.,
"Dominant cone-rod dystrophy: a mouse model generated by gene targeting of the GCAP1/Guca1a gene."
PLoS One 2011;6(3):e18089
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All: |
1 reference(s)
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Analysis Tools
