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| Nomenclature |
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Symbol:
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Cacna1atm1.1Sher
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Name:
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calcium channel, voltage-dependent, P/Q type, alpha 1A subunit;
targeted mutation 1.1, Stefan Herlitze
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MGI ID: |
MGI:4949728 |
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Synonyms: |
Cacna1aCitrine, Cacna1atm-Citrine+ |
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Gene:
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Cacna1a
Location:
Chr8:84388440-84640246 bp, + strand
Genetic Position: Chr8,
40.95 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:170451
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutation: | |
Insertion |
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Mutation details: A cassette, which contained (5' to 3') a loxP site, citrine reporter, duplicate exon 1, second loxP site, neo cassette, and third loxP site, was inserted downstream of exon 1. Cre-mediated recombination removed the neo cassette while the floxed citrine reporter and duplicate exon 1 remain intact. (J:170451)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Cacna1a Mutation:
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43 strains or lines available |
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| References |
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Original: |
J:170451
Mark MD et al.,
"Delayed Postnatal Loss of P/Q-Type Calcium Channels Recapitulates the Absence Epilepsy, Dyskinesia, and Ataxia Phenotypes of Genomic Cacna1A Mutations."
J Neurosci 2011 Mar 16;31(11):4311-26
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All: |
1 reference(s)
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Analysis Tools
