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| Nomenclature |
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Symbol:
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Foxo3mommeR1
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Name:
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forkhead box O3;
modifier of murine metastable epialleles, R1
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MGI ID: |
MGI:4949204 |
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Synonyms: |
MommeR1 |
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Gene:
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Foxo3
Location:
Chr10:42181841-42276755 bp, - strand
Genetic Position: Chr10,
22.79 cM
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Mutation
origin |
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Mutation
description |
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Allele
Type: | |
Chemically induced (ENU) |
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Mutation: | |
Single point mutation |
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Mutation details: Mice carrying Tg(Hba1-Gfp)1Ew were treated with ENU. ENU induced a T to A transition in exon 2 that changes an isoleucine to asparagine in the highly conserved Forkhead domain. Northern and western blot analysis indicate this mutation does not greatly affect mRNA or protein expression. (J:99816, J:170710)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Foxo3 Mutation:
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13 strains or lines available |
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| References |
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Original: |
J:170710
Youngson NA et al.,
"A missense mutation in the transcription factor Foxo3a causes teratomas and oocyte abnormalities in mice."
Mamm Genome 2011 Apr;22(3-4):235-48
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All: |
2 reference(s)
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Analysis Tools
