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| Nomenclature |
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Symbol:
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Csrp3tm1.1Rkn
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Name:
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cysteine and glycine-rich protein 3;
targeted mutation 1.1, Ralph Knoll
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MGI ID: |
MGI:4947957 |
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Synonyms: |
MlpW4R |
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Gene:
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Csrp3
Location:
Chr7:48830398-48848051 bp, - strand
Genetic Position: Chr7,
31.11 cM, cytoband B3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:170878
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Single point mutation |
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Mutation details: Exon 2 was replaced with one in which a T to C transition results in the amino acid substitution of arginine for tryptophan at position 4 (W4R). A floxed neo cassette inserted downstream of the modified exon 2 was removed by cre-mediated recombination. Reduced protein expression was confirmed by western blot analysis. (J:170878)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Csrp3 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:170878
Knoll R et al.,
"A common MLP (muscle LIM protein) variant is associated with cardiomyopathy."
Circ Res 2010 Mar 5;106(4):695-704
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All: |
1 reference(s)
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Analysis Tools
