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| Nomenclature |
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Symbol:
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Juptm1.1Glr
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Name:
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junction plakoglobin;
targeted mutation 1.1, Glenn L Radice
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MGI ID: |
MGI:4947239 |
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Synonyms: |
PGflox |
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Gene:
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Jup
Location:
Chr11:100368958-100397763 bp, - strand
Genetic Position: Chr11,
63.47 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:170618
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Parent Cell Line:
| TL1/TL-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP site was inserted upstream of exon 1, and a loxP site and an FRT-flanked neo cassette were introduced into intron 1 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 1 floxed. (J:170618)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:170618
Li J et al.,
"Cardiac tissue-restricted deletion of plakoglobin results in progressive cardiomyopathy and activation of {beta}-catenin signaling."
Mol Cell Biol 2011 Mar;31(6):1134-44
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All: |
3 reference(s)
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Analysis Tools
