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| Nomenclature |
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Symbol:
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Braftm1Bbd
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Name:
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Braf transforming gene;
targeted mutation 1, Mariano Barbacid
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MGI ID: |
MGI:4946645 |
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Synonyms: |
B-RafLSLV600E |
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Gene:
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Braf
Location:
Chr6:39603237-39725463 bp, - strand
Genetic Position: Chr6,
18.43 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:170095
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: An FRT site and a floxed pgk-hygromycin stop cassette were inserted in intron 14, a GTG to GAG mutation was created in codon 600 and an FRT site was inserted into intron 15 via homologous recombination. RT-PCR analysis indicates the mutant allele is expressed at about 5-10% of the level of the wild-type allele. (J:170095)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:170095
Urosevic J et al.,
"Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome."
Proc Natl Acad Sci U S A 2011 Mar 22;108(12):5015-20
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All: |
1 reference(s)
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Analysis Tools
