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| Nomenclature |
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Symbol:
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Sepn1tm1.2Mred
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Name:
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selenoprotein N, 1;
targeted mutation 1.2, Mathieu Rederstorff
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MGI ID: |
MGI:4946396 |
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Gene:
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Sepn1
Location:
Chr4:134537892-134552166 bp, - strand
Genetic Position: Chr4,
66.85 cM, cytoband D3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:168699
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A loxP site was inserted upstream of exon 3. A floxed neo cassette was inserted downstream of exon 3. Cre-mediated recombination removed exon 3 and the neo cassette. Western blot analysis on skeletal muscle. heart, lung, liver, brain, and kidney extracts confirmed the absence of protein expression. (J:176499)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:168699
Castets P et al.,
"Satellite cell loss and impaired muscle regeneration in selenoprotein N deficiency."
Hum Mol Genet 2011 Feb 15;20(4):694-704
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All: |
2 reference(s)
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Analysis Tools
