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| Nomenclature |
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Symbol:
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Tg(Kit*D814V)3Roer
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Name:
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transgene insertion 3, Axel Roers
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MGI ID: |
MGI:4942359 |
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Synonyms: |
kitD814Vflox |
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Transgene:
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Tg(Kit*D814V)3Roer
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene consists of the mouse BAC clone RP23-274L11 which contains the entire Kit locus. The Kit locus in the BAC was modified by the insertion of a floxed stop cassette into intron 1 and the insertion of an A to T point mutation in exon 17 resulting in an aspartic acid to valine mutation at position 814. This mutation is homologous to the D816V mutation in humans. This line carries 2 copies of the transgene. Analysis of the residual vector backbone indicates the transgenes in this line may not be intact. (J:169611)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:169611
Gerbaulet A et al.,
"Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit."
Blood 2011 Feb 10;117(6):2012-21
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All: |
1 reference(s)
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Analysis Tools
