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| Nomenclature |
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Symbol:
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Tg(Kit*D814V)2Roer
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Name:
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transgene insertion 2, Axel Roers
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MGI ID: |
MGI:4942358 |
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Synonyms: |
kitD814Vflox |
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Transgene:
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Tg(Kit*D814V)2Roer
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene consists of the mouse BAC clone RP23-274L11 which contains the entire Kit locus. The Kit locus in the BAC was modified by the insertion of a floxed stop cassette into intron 1 and the insertion of an A to T point mutation in exon 17 resulting in an aspartic acid to valine mutation at position 814. This mutation is homologous to the D816V mutation in humans. This line carries more than 10 copies of the transgene. (J:169611)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:169611
Gerbaulet A et al.,
"Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit."
Blood 2011 Feb 10;117(6):2012-21
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All: |
1 reference(s)
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Analysis Tools
