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| Nomenclature |
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Symbol:
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Tg(Prnp-SNCA*A53T)25Mkle
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Name:
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transgene insertion 25, Michael K Lee
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MGI ID: |
MGI:4942280 |
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Synonyms: |
N2-5 |
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Transgene:
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Tg(Prnp-SNCA*A53T)25Mkle
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C3H/HeJ x C57BL/6J)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene contains a human alpha synuclein cDNA encoding the Ala53Thr amino acid substitution, and the murine prion promoter. Lines G2-3, H5, and N2-5 were generated (J:77344)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:77344
Lee MK et al.,
"Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice."
Proc Natl Acad Sci U S A 2002 Jun 25;99(13):8968-73
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All: |
2 reference(s)
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Analysis Tools
