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| Nomenclature |
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Symbol:
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Qpcttm1.2Tbay
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Name:
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glutaminyl-peptide cyclotransferase (glutaminyl cyclase);
targeted mutation 1.2, Thomas A Bayer
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MGI ID: |
MGI:4941596 |
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Gene:
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Qpct
Location:
Chr17:79051906-79090243 bp, + strand
Genetic Position: Chr17,
49.83 cM, cytoband E3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:169481
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: LoxP sites were inserted into intron 3 and 5. Flp-mediated recombination removed the FRT-flanked neo cassette, and cre-mediated recombination removed exons 4 and 5. The absence of transcript expression was confirmed by RT-PCR. (J:169481)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Qpct Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:169481
Jawhar S et al.,
"Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate A{beta} formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice."
J Biol Chem 2011 Feb 11;286(6):4454-60
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All: |
3 reference(s)
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Analysis Tools
