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| Nomenclature |
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Symbol:
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Lhx3tm1.1Sjr
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Name:
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LIM homeobox protein 3;
targeted mutation 1.1, Simon J Rhodes
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MGI ID: |
MGI:4941330 |
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Synonyms: |
Lhx3W227ter, Lhx3W227ter Neo(-) |
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Gene:
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Lhx3
Location:
Chr2:26200212-26208289 bp, - strand
Genetic Position: Chr2,
18.44 cM, cytoband A2-C1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:169035
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Parent Cell Line:
| CCE916 (ES Cell) |
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Strain of Origin:
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129S/SvEv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Single point mutation |
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Mutation details: A floxed neo cassette was inserted and a tryptophan to stop mutation was introduced at amino acid 227 via homologous recombination. Cre mediated recombination removed the neo cassette. This mutation results in a truncated protein that lacks the carboxyl terminus. (J:169035)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:169035
Colvin SC et al.,
"Model of pediatric pituitary hormone deficiency separates the endocrine and neural functions of the LHX3 transcription factor in vivo."
Proc Natl Acad Sci U S A 2011 Jan 4;108(1):173-8
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All: |
2 reference(s)
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Analysis Tools
