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| Nomenclature |
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Symbol:
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Tg(Col2a1*R789C)#Waho
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Name:
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transgene insertion, William A Horton
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MGI ID: |
MGI:4941021 |
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Transgene:
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Tg(Col2a1*R789C)#Waho
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x DBA/2)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: An Arg789Cys mutation (a C-to-T transition in exon 41) was engineered in the murine type II collagen (Col2a1). A second silent mutation was introduced to create a SmaI cleavage site in exon 41 used for monitoring the presence of the transgene. Five founders were created and progeny from two of these founders were analyzed. (J:112540)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:112540
Gaiser KG et al.,
"Y-position collagen II mutation disrupts cartilage formation and skeletal development in a transgenic mouse model of spondyloepiphyseal dysplasia."
J Bone Miner Res 2002 Jan;17(1):39-47
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All: |
1 reference(s)
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Analysis Tools
