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| Nomenclature |
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Symbol:
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Tg(Prnp-ATXN3*79Q)#Hlw
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Name:
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transgene insertion, Hung-Li Wang
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MGI ID: |
MGI:4940057 |
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Synonyms: |
Ataxin-3-Q79 |
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Transgene:
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Tg(Prnp-ATXN3*79Q)#Hlw
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The mouse promoter drive neuronal expression of the HA-tagged human cDNA with a trinucleotide repeat that results in a 79 glutamine stretch. This amplification of the glutamine tract is associated with Spinocerebellar Ataxia 3 (SCA3) in humans. Two lines with more than five copies of the transgene were generated. The pound symbol (#) denotes when no line number is specified and/or lines are pooled. (J:138381)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:138381
Chou AH et al.,
"Polyglutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation."
Neurobiol Dis 2008 Jul;31(1):89-101
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All: |
2 reference(s)
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Analysis Tools
