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| Nomenclature |
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Symbol:
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Ren1tm1.2Sig
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Name:
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renin 1 structural;
targeted mutation 1.2, Curt Sigmund
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MGI ID: |
MGI:4939806 |
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Synonyms: |
sRen- |
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Gene:
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Ren1
Location:
Chr1:133350510-133360325 bp, + strand
Genetic Position: Chr1,
57.91 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:169129
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Parent Cell Line:
| Other (see notes) (ES Cell) |
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Strain of Origin:
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C57BL/6J-Tyrc-2J
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Mutation
description |
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Allele
Type: | |
Targeted (other) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Cre-mediated recombination of Ren1tm1.1Sig removed exon 1a (Ia). The absence of the transcript encoding the secreted isoform was confirmed by RT-PCR. Expression of the transcript encoding the intracellular isoform is maintained. (J:169129)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ren1 Mutation:
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5 strains or lines available |
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Notes |
ES cell = SCR (C57BL/6J-Tyrc-2J)
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| References |
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Original: |
J:169129
Xu D et al.,
"Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin."
Hypertension 2009 Dec;54(6):1240-7
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All: |
1 reference(s)
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Analysis Tools
