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| Nomenclature |
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Symbol:
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Hcn4tm1.1Ggc
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Name:
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hyperpolarization-activated, cyclic nucleotide-gated K+ 4;
targeted mutation 1.1, Giacomo Consalez
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MGI ID: |
MGI:4888968 |
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Synonyms: |
Hcn4lox, Hcn4tm1.1Ddf |
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Gene:
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Hcn4
Location:
Chr9:58823512-58860955 bp, + strand
Genetic Position: Chr9,
31.8 cM, cytoband C
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:168248
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S/SvEv
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: An FRT flanked neomycin selection cassette was inserted upstream of exon 2 and exon 2 was flanked with loxP sites. Mice were then crossed to transgenic mice expressing flp recombinase to excise the neomycin selection cassette. (J:168248)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Hcn4 Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:168248
Baruscotti M et al.,
"Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4."
Proc Natl Acad Sci U S A 2011 Jan 25;108(4):1705-10
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All: |
1 reference(s)
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Analysis Tools
