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| Nomenclature |
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Symbol:
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Aestm1.1Mmt
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Name:
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amino-terminal enhancer of split;
targeted mutation 1.1, Makoto M Taketo
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MGI ID: |
MGI:4888012 |
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Synonyms: |
Aesf |
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Gene:
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Aes
Location:
Chr10:81559560-81566364 bp, + strand
Genetic Position: Chr10,
39.72 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:168065
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Parent Cell Line:
| D3a2 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: Exon 2 was flanked by two loxP sites, and after the first loxP site a PGK-Neo cassette flanked by FRT sequences was inserted into intron 1 immediately 5' to exon 2. The PGK-Neo selection sequence was removed by FLPe-mediated recombination. (J:168065)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Aes Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:168065
Sonoshita M et al.,
"Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch Signaling."
Cancer Cell 2011 Jan 18;19(1):125-37
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All: |
1 reference(s)
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Analysis Tools
