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| Nomenclature |
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Symbol:
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Ucp2tm2.1Lowl
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Name:
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uncoupling protein 2 (mitochondrial, proton carrier);
targeted mutation 2.1, Bradford B Lowell
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MGI ID: |
MGI:4887236 |
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Synonyms: |
Ucp2lox |
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Gene:
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Ucp2
Location:
Chr7:100493337-100502020 bp, + strand
Genetic Position: Chr7,
54.36 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:167906
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Parent Cell Line:
| W4 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A targeting construct was used to introduce loxP sites into intron 2 and intron 6 of Ucp2, as well as an FRT-flanked kanamycin selection cassette. Homologous recombination in W4 ES cells was used to generate the floxed allele. Chimeras were bred to Flp recombinase expressing mice to remove the selection marker cassette. (J:167906)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ucp2 Mutation:
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25 strains or lines available |
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| References |
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Original: |
J:167906
Kong D et al.,
"Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis."
Cell Metab 2010 Nov 3;12(5):545-52
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All: |
2 reference(s)
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Analysis Tools
