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| Nomenclature |
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Symbol:
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Mir146tm1.1Bal
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Name:
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microRNA 146;
targeted mutation 1.1, David Baltimore
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MGI ID: |
MGI:4882045 |
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Gene:
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Mir146
Location:
Chr11:43374397-43374461 bp, - strand
Genetic Position: Chr11,
25.68 cM
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Enlarged spleen and lymph nodes and multiorgan inflammation in Mir146tm1.1Bal/Mir146tm1.1Bal and Mir146tm2.1Bal/Mir146tm2.1Bal mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:167922
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Parent Cell Line:
| Bruce 4 (ES Cell) |
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Strain of Origin:
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B6.Cg-Thy1a
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The 295 bp of the pre-microRNA was replaced with a floxed neo cassette. Cre-mediated recombination removed the neo cassette. The absence of transcript expression was confirmed by qRT-PCR on bone marrow, spleen, and thymus extracts. (J:173671)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:167922
Lu LF et al.,
"Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses."
Cell 2010 Sep 17;142(6):914-29
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All: |
5 reference(s)
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Analysis Tools
