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| Nomenclature |
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Symbol:
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Phgdhtm1.2Shfu
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Name:
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3-phosphoglycerate dehydrogenase;
targeted mutation 1.2, Shigeki Furuya
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MGI ID: |
MGI:4881750 |
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Synonyms: |
Phgdhflox |
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Gene:
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Phgdh
Location:
Chr3:98313170-98339990 bp, - strand
Genetic Position: Chr3,
42.74 cM, cytoband E1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:167572
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A floxed neo cassette was inserted upstream of exon 4, and an additional loxP site was inserted downstream of exon 5. The neo cassette, exon 4, and exon 5 were removed by cre-mediated recombination. Cre-mediated recombination removed the neo cassette leaving exon 4 and 5 floxed. (J:167572)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Phgdh Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:167572
Yang JH et al.,
"Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain."
J Biol Chem 2010 Dec 31;285(53):41380-90
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All: |
1 reference(s)
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Analysis Tools
