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| Nomenclature |
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Symbol:
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Pld2tm1.1Gdp
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Name:
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phospholipase D2;
targeted mutation 1.1, Gilbert Di Paolo
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MGI ID: |
MGI:4880012 |
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Gene:
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Pld2
Location:
Chr11:70540064-70558110 bp, + strand
Genetic Position: Chr11,
42.99 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:166741
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (other) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A loxP site was inserted downstream of exon 13, and an FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 15. Cre-mediated recombination removed exons 13 through 15 and the neo cassette. The reduction in protein expression was confirmed by western blot analysis. (J:166741)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pld2 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:166741
Oliveira TG et al.,
"Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits."
J Neurosci 2010 Dec 8;30(49):16419-28
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All: |
3 reference(s)
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Analysis Tools
