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| Nomenclature |
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Symbol:
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Mybboo
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Name:
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myeloblastosis oncogene;
booreana
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MGI ID: |
MGI:4867909 |
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Gene:
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Myb
Location:
Chr10:21124930-21160984 bp, - strand
Genetic Position: Chr10,
9.75 cM
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Mutation
origin |
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Strain of Origin:
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C57BL/6
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Mutation
description |
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Allele
Type: | |
Chemically induced (ENU) |
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Mutation: | |
Single point mutation |
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Mutation details: This mutation was identified in a screen of ENU mutations for hematopoietic system phenotypes. An A to G transition was identified at position 923 in exon 8. This results in a Glutamic acid to Glycine change of amino acid residue 308 affecting the transactivation domain. (J:167270)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Myb Mutation:
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7 strains or lines available |
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Notes |
Phenotypic Similarity to Human Syndrome: Thrombocythemia in homozygous mice (J:167270)
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| References |
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Original: |
J:167270
Papathanasiou P et al.,
"A recessive screen for genes regulating hematopoietic stem cells."
Blood 2010 Dec 23;116(26):5849-58
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All: |
1 reference(s)
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Analysis Tools
