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| Nomenclature |
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Symbol:
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Gbatm1.1Pmis
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Name:
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glucosidase, beta, acid;
targeted mutation 1.1, Pramod K Mistry
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MGI ID: |
MGI:4867659 |
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Synonyms: |
GBA1LoxP |
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Gene:
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Gba
Location:
Chr3:89202928-89208681 bp, + strand
Genetic Position: Chr3,
39.01 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:167081
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A floxed neo cassette was inserted upstream of exon 8 and an additional loxP site was inserted downstream of exon 11. Cre-mediated recombination removed the neo cassette leaving exons 8 through 11 floxed. (J:167081)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gba Mutation:
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10 strains or lines available |
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| References |
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Original: |
J:167081
Mistry PK et al.,
"Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage."
Proc Natl Acad Sci U S A 2010 Nov 9;107(45):19473-8
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All: |
2 reference(s)
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Analysis Tools
