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| Nomenclature |
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Symbol:
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Tg(DYRK1A)36Wjs
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Name:
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transgene insertion 36, Woo-Joo Song
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MGI ID: |
MGI:4867514 |
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Synonyms: |
DYRK1A BAC TG |
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Transgene:
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Tg(DYRK1A)36Wjs
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6NCrjBgi
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene consists of a bacterial artificial chromosome clone containing the complete human DYRK1A genomic DNA fragment, including the endogenous promoter (777J19 BAC clone from the RPCI-11 human BAC library). FISH and quantitative PCR analysis shows a single chromosomal integration of the DNA and about a 1.5-fold overexpression of total Dyrk1a (both mouse and human) protein. Two lines 36 and 46 were created, with line 36 entered as the representative line. (J:111293)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:111293
Ahn KJ et al.,
"DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects."
Neurobiol Dis 2006 Jun;22(3):463-72
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All: |
2 reference(s)
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Analysis Tools
