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| Nomenclature |
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Symbol:
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Tg(Spo11-cre)D5Mpel
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Name:
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transgene insertion D5, Manuela Pellegrini
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MGI ID: |
MGI:4850038 |
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Synonyms: |
Spo11Cre, Spo11-IRES-Cre |
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Transgene:
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Tg(Spo11-cre)D5Mpel
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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BALB/c x C57BL/6
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Transgene
description |
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Transgene
Type: | |
Transgenic (Cre/Flp) |
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Mutation: | |
Insertion |
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Mutation details: The BAC RP23-20N4 containing the entire Spo11 locus (including 188kb of sequence upstream of the initiation codon and 57kb downstream of the stop codon) was engineered by homologous recombination to insert an IRES-cre-(Frt-flanked) neo fragment immediately downstream of the stop codon. The neo was subsequently removed by Flp in bacteria. The modified BAC was injected into the pronuclei of fertilized eggs. Two named lines, D5 and H9, were generated and studied further. (J:166888)
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Recombinase activity
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Driver:
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Spo11
Summary of all recombinase alleles
driven by Spo11.
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MGI has not yet included tissue activity data for this allele in any anatomical systems.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:166888
Pellegrini M et al.,
"Targeted JAM-C deletion in germ cells by Spo11-controlled Cre recombinase."
J Cell Sci 2011 Jan 1;124(Pt 1):91-9
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All: |
1 reference(s)
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Analysis Tools
