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| Nomenclature |
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Symbol:
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Tg(Igh-TCL1A)1Ypek
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Name:
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transgene insertion 1, Yuri Pekarsky
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MGI ID: |
MGI:4850003 |
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Synonyms: |
Emu-TCL1FL |
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Transgene:
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Tg(Igh-TCL1A)1Ypek
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A 1.3 kb fragment encoding the entire human TCL1A coding region and both 5' and 3' UTR was placed under the transcriptional control of the mouse Igh-V186.2 promoter and the Igh-mu enhancer sequence. 3'UTR and polyA sequences were derived from the human Beta-globin gene. The Emu enhancer drives B cell-specific expression. Two lines were generated (lines 1 and 4). (J:160184)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:160184
Efanov A et al.,
"CD5+CD23+ leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation."
Leukemia 2010 May;24(5):970-5
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All: |
2 reference(s)
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Analysis Tools
