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| Nomenclature |
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Symbol:
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Tg(Prnp-SOD1*G37R,-PSEN1)110Dbo
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Name:
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transgene insertion 110, David R Borchelt
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MGI ID: |
MGI:4849838 |
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Transgene:
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Tg(Prnp-SOD1*G37R,-PSEN1)110Dbo
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x C3H)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The mouse promoter drives neuronal expression of human SOD1 containing the G37R mutation found in patients with familial amyotrophic lateral sclerosis. This transgene was co-injected with Tg(PSEN1)S8-4Dbo. Two lines were generated (39 and 110). (J:104655)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:104655
Wang J et al.,
"Coincident thresholds of mutant protein for paralytic disease and protein aggregation caused by restrictively expressed superoxide dismutase cDNA."
Neurobiol Dis 2005 Dec;20(3):943-52
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All: |
2 reference(s)
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Analysis Tools
